Correlative Microscopy

Nanotechnology deployed in novel ways

From the organ level to the single molecule.

Ingham Institute’s Correlative Microscopy Facility houses one of the most powerful microscopes of its type in the world.

From the Organ Level to the Single Molecule

The Correlative Microscopy Facility at the Ingham Institute for Applied Medical Research is home to one of the most advanced microscopy platforms in Australia, offering unique capabilities in visualising cellular and subcellular structures at the nanometer scale (10 -9 metres). By combining cutting-edge imaging technologies with nanotechnology and cryogenic tissue preservation, our facility enables unprecedented insights into human disease processes.

What We Do

Our team applies correlative microscopy—a powerful technique that integrates light microscopy, super-resolution imaging, and field emission scanning electron microscopy (FESEM) to correlate structural and functional features in a single tissue specimen. This allows researchers to track biomarkers, understand disease progression, and assess therapeutic response with high precision.

Our current research focus areas include:

  • Cancer cell biology and clinical imaging correlation
  • Atherosclerosis blood test development
  • Chronic kidney disease (CKD) and acute renal disease pathobiology
  • Age-related macular degeneration (AMD) and retinal disease pathogenesis
  • Neuroscience and neurodegeneration
  • Novel nanotechnology-based diagnostics
  • Materials research and biomedical device design.

Our Technology

Our facility houses two flagship instruments:

  • Carl Zeiss GeminiSEM 300 FESEM
    A first-of-its-kind in Australia, this microscope is dedicated to the detection of cancer biomarkers in human tissue, providing ultra-high-resolution imaging of cellular ultrastructure.
  • Zeiss LSM 800 Super-Resolution Confocal Laser Scanning Microscope (SRLSM)
    Designed for high-speed, live-cell imaging with exceptional resolution and sensitivity, this instrument is ideal for dynamic studies and molecular localisation in cells and tissues.

Applications Across Disciplines

Our expertise and equipment support a wide range of research applications, including biomedical research, cell pathology, ultrastructural disease analysis, cancer biomarker detection as well as drug delivery tracking and nanoparticle localisation.

Collaborate with Us

We provide:

  • Training for academic, clinical, and commercial users
  • Research collaboration opportunities
  • Full-service microscopy support from project planning to image analysis

Whether you are part of a university research team, a biotechnology company, or an industry partner, we welcome collaborations that aim to explore and solve complex biomedical challenges using state-of-the-art microscopy and correlative biochemical analysis.

Prof Murray Killingsworth

Lead, Correlative Microscopy Facility
Ingham Institute

Dr Tzipi Cohen-Hyams

Lead, Correlative Microscopy Facility
Ingham Institute

“The newly developed desktop electron microscope represents an important step forward in accessibility to high-resolution imaging. With the ability to visualise fine structural details—such as proteins, viruses, and cellular changes linked to renal disease, cancer, and rare conditions—it offers strong diagnostic potential in a compact, cost-effective format. This makes it feasible for use in smaller, regional, and rural laboratories, helping bring advanced diagnostic capabilities closer to communities outside major metropolitan centres.

It’s a practical innovation that supports more timely, equitable access to diagnostic tools across Australia.”

Dr Tzipi Cohen-Hyams