Professor Nick Shackel leads the Gastroenterology and Liver Laboratory at the Ingham Institute and Liverpool Hospital. He is a Professor of Medicine and Gastroenterology at the University of New South Wales, a Senior Clinician within the Department of Gastroenterology and Liver at Liverpool Hospital, a PhD Scientist and Liver Researcher. Prof Shackel leads a program in functional genomics to better understand cirrhosis and liver cancer, as well as using transgenic animals to model human liver disease. Clinical research undertaken by his group examines the side effects of check-point inhibitors, microbiome relationship to liver disease severity, treatment of cramps, predictors of liver injury and nutritional interventions in end stage liver disease.
The research Prof Shackel has led has made a number of highly significant and novel discoveries in liver disease including
Prof Shackel is an Australia Liver Association and a Transplant Society of Australia and New Zealand council member. He has helped draft national policy in areas as diverse as the utilisation of potentially infectious organ donors for transplantation and the ethics of tissue utilisation in research. Prof Shackel balances his clinical commitments with supervision of the laboratory, directing research ranging from next generation sequencing to understanding the effects of nutritional interventions in cirrhosis. He is a regular National Health and Medical Research Council (NHMRC) panel member, reviewer for multiple journals and has collaborations in Europe and North America. Prof Shackel demonstrates an active commitment to teaching of all students from undergraduates through to RACP exam candidates and mentors many young researchers.
